Cyclic-AMP Dependent Protein Kinase Activity in the Soluble Thyrotropin Receptor Complex
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منابع مشابه
by cyclic AMP-dependent protein kinase
Myosin light-chain kinase was purifed from bovine carotid artery. Approx. 90% of myosin kinase was extracted in the supernatant fraction with buffer containing EDTA during myofibril preparation. The soluble fraction yielded two distinct peaks on DEAE-Sephacel chromatography. Peak I was eluted at a conductance of 11-12mmho and was completely dependent on Ca2+-calmodulin for its activity. Peak II...
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The pancreatic acinar cell has several phenotypic responses to cAMP agonists. At physiological concentrations of the muscarinic agonist carbachol (1 microM) or the CCK analog caerulein (100 pM), ligands that increase cytosolic Ca(2+), cAMP acts synergistically to enhance secretion. Supraphysiological concentrations of carbachol (1 mM) or caerulein (100 nM) suppress secretion and cause intracell...
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Cholinergic and f-adrenergic stimulations of ionic currents are major physiological mechanisms in the regulation of heart rate and contractility. Muscarinic receptor stimulation is known to reduce f-adrenergic effects on calcium current via reduction of cyclic AMP. Whether the P-adrenergic stimulation affects the muscarinic response is not known. I report here that the f8-adrenergic agonist iso...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1980
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.56.5_724